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Relationship between wave reflection and renal damage in hypertensive patients

Stea, Francesco and Sgrò, Melania and Faita, Francesco and Bruno, Rosa M. and Cartoni, Giulia and Armenia, Sabina and Taddei, Stefano and Ghiadoni, Lorenzo (2013) Relationship between wave reflection and renal damage in hypertensive patients. Journal of Hypertension, 31 (12). pp. 2418-2424. ISSN 0263-6352

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    OBJECTIVE: Arterial stiffening has harmful effects; peripheral pulse wave reflections deleteriously increase central pressure, but on the contrary they could also possibly be protective, as the pulse is transmitted to the microcirculation to a lesser extent. The aim of this study was, therefore, to explore the relationship between wave reflection and small vessel damage in the kidney. METHODS: In 216 hypertensive patients, data on renal resistive index, obtained by Doppler ultrasound sampling of the interlobar arteries, as well as augmentation index (AIx) and carotid-to-femoral pulse wave velocity (PWV), were retrospectively analyzed. Reflection magnitude was computed through a triangular flow estimate. RESULTS: AIx and reflection magnitude were positively correlated with resistive index; age, BMI, central pulse pressure, and cholesterol, but not AIx or reflection magnitude, were predictors of resistive index in multivariate analyses. Crossing tertiles of PWV and AIx, resistive index did not differ between patients with high AIx and low PWV (n=25; 0.632 (0.064)) and those with low AIx and high PWV (n=17; 0.645 (0.053)), despite a difference in reflection magnitude (74.9 (6.7) vs. 51.2 (7.3)%; P<0.001). CONCLUSION: Pressure wave reflection is positively correlated with resistive index in a hypertensive population. No negative relationship was found even adjusting for confounders or when it was examined separately from the influence of arterial stiffness. These findings do not support the hypothesis of peripheral wave reflections having a significant protective role for the microcirculation of a low resistance vascular bed such as the kidney.

    Item Type: Article
    Additional Information: Pre-publication draft with corrections
    Subjects: Area06 - Scienze mediche > MED/11 - Malattie dell'apparato cardiovascolare
    Depositing User: Dr. Francesco Stea
    Date Deposited: 06 Mar 2015 14:31
    Last Modified: 06 Mar 2015 14:31
    URI: http://eprints.adm.unipi.it/id/eprint/2320

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