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L'affinità e la concentrazione. I meccanismi molecolari della regolazione del metabolismo.

Gabrielli di Quercita, Franco (2010) L'affinità e la concentrazione. I meccanismi molecolari della regolazione del metabolismo. SEU. Servizio Editoriale di Pisa, Pisa, IT.

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    Abstract

    Concentration and affinity of reactants determine the chemical equilibrium, and the biological reactions between proteins and their ligands behave like chemical reactions at a constant temperature. In cells, affinity between proteins and ligands can be regulated through changes in protein structure induced either by molecular effectors or by covalent reactions. Hemoglobin affinity towards oxygen is regulated by two different molecular mechanisms: the oxygen cooperative effect and proton and diphosphoglycerate allosteric effects. Metabolic pathways are made of sequences of enzymatic proteins, where the product of a given enzymatic reaction is a substrate of the enzyme positioned next in the metabolic pathway. One or few pacemaker enzymes, placed in strategic positions, regulate the metabolic pathways. The pacemaker enzymes are regulated in their catalytic activity by metabolites and/or covalent reactions and, through these mechanisms, they regulate the whole metabolism. Given the same metabolic conditions, the regulation of the same metabolic pathways placed in different human tissues can be very different.

    Item Type: Book
    Subjects: Area05 - Scienze biologiche > BIO/11 - Biologia molecolare
    Divisions: Dipartimenti (until 2012) > DIPARTIMENTO DI PATOLOGIA SPERIMENTALE, BIOTECNOLOGIE MEDICHE, INFETTIVOLOGIA ED EPIDEMIOLOGIA
    Depositing User: dott.ssa Sandra Faita
    Date Deposited: 05 Nov 2015 11:09
    Last Modified: 05 Nov 2015 11:27
    URI: http://eprints.adm.unipi.it/id/eprint/2350

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