Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells

Landi, Martina and Catelani, Giorgio and D’Andrea, Felicia and Ghidini, Eleonora and Amari, Gabriele and Puccini, Paola and Bianchi, Nicoletta and Gambari, Roberto (2009) Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells. European Journal of Medicinal Chemistry, 44 (2). pp. 745-754. ISSN 0223-5234

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Abstract

SUMMARY A series of carbamides derived from 1,2:5,6-di-O-isopropylidene-D-gluco- (1) and D-allofuranose (3) as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alfa- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described.

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